METHODS OF USE OF PEPTIDE DEFORMYLASE INHIBITORS AS NOVEL ANTIBACTERIAL AGENTS

摘要

The present invention relates to novel drug discovery assays which specifically target peptide deformylase containing the typically unstable native catalytic iron metal center. The present invention further relates to methods of identifying compounds which have greater than 10-fold, and preferably greater than 100-fold selectivity for peptide deformylase over other metalloproteases. The invention further provides for compounds having antibacterial activity identified by the assays of the invention, methods of using the compounds to treat bacterial infections and pharmaceutical compositions containing the compounds of the invention.