COMPOUNDS FOR THE ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION
摘要
Amyloid binding compounds which are derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloidosis, such as Down's Syndrome are described. Pharmaceutical compositions containing Chrysamine G and derivatives thereof and methods using such compositions to prevent cell degeneration and amyloid-induced toxicity in amyloidosis associated conditions are also described. Methods using Chrysamine G derivatives to stain or detect amyloid deposits in biopsy or post-mortem tissue are also described. Methods using Chrysamine G derivatives to quantify amyloid deposits in homogenates of biopsy and post-mortem tissue are also described.
申请公布号
WO9924394(A9)
申请公布日期
2001.05.31
申请号
WO1998US23598
申请日期
1998.11.06
申请人
UNIVERSITY OF PITTSBURGH;KLUNK, WILLIAM, E.;PETTEGREW, JAY, W.;MATHIS, CHESTER, A., JR.
发明人
KLUNK, WILLIAM, E.;PETTEGREW, JAY, W.;MATHIS, CHESTER, A., JR.