发明名称 |
Stabilized thyroxine compounds |
摘要 |
Throxinyldimethylphosphinate was invented as a prodrug to stabilize thyroxine, a drug widely used to treat hypothyroidism. The presence of the dimethylphosphinate group at the phenolic hydroxyl of thyroxine is key to preventing thyroxine from decomposing through the proposed pathway. The prodrug will be hydrolyzed in the stomach or the gut into thyroxine and the biologically inert dimethylphosphinic acid. Related products may be stabilized with the same or similar protecting groups. |
申请公布号 |
AU1488001(A) |
申请公布日期 |
2001.05.30 |
申请号 |
AU20010014880 |
申请日期 |
2000.11.15 |
申请人 |
LOTUS BIOCHEMICAL CORPORATION |
发明人 |
THOMAS PICCARIELLO;ANNE F. LECLERCQ |
分类号 |
A61K31/198;A61P5/14 |
主分类号 |
A61K31/198 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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