发明名称 |
THE SEMAPHORIN GENE FAMILY |
摘要 |
A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular a nd animal systems for the development of neurological disease therapy.
|
申请公布号 |
CA2171638(C) |
申请公布日期 |
2001.05.29 |
申请号 |
CA19942171638 |
申请日期 |
1994.09.13 |
申请人 |
|
发明人 |
GOODMAN, COREY S.;KOLODKIN, ALEX L.;MATTHES, DAVID;BENTLEY, DAVID R.;O'CONNOR, TIMOTHY |
分类号 |
A01K67/027;A01K67/033;A61K38/00;A61K39/395;A61P25/00;A61P31/12;A61P35/00;A61P37/00;C07H21/04;C07K7/06;C07K7/08;C07K14/07;C07K14/435;C07K14/47;C07K14/705;C07K16/18;C12N5/10;C12N15/09;C12N15/85;C12P21/02;C12Q1/00;C12Q1/68;C12R1/91;G01N33/15;G01N33/50;G01N33/53;G01N33/566;(IPC1-7):C12N15/18;A61K38/18;C07K16/22;C07K14/48 |
主分类号 |
A01K67/027 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|