发明名称 |
Kondenserte polycykliske heterosyklusderivater, fremstilling og anvendelse av slike forbindelser, samt preparater og midler omfattende slike forbindelser |
摘要 |
Novel fused polycyclic heterocycle derivatives having excellent antitumor effects and a process for producing the same. A compound represented by the following general formula (I) or pharmacologically acceptable salts thereof: <CHEM> wherein the ring A represents an optionally substituted monocyclic aromatic ring or a dicyclic fused ring in which at least one of the rings is an aromatic ring; the ring B represents pyrrole, 4H-1,4-oxazine, 4H-1,4-thiazine or 4(1H)-pyridone; the ring C represents an optionally substituted, monocyclic or dicyclic fused aromatic ring; and Y represents a group represented by the formula -e-f (wherein e represents a lower alkylene; and f represents amidino, guanidino or amino optionally substituted by optionally hydroxylated or optionally lower-alkylaminated lower alkyl; provided that the cases where the rings A and B are both optionally substituted monocyclic aromatic rings are excluded. Which has an excellent antitumor activity. |
申请公布号 |
NO310149(B1) |
申请公布日期 |
2001.05.28 |
申请号 |
NO19970005493 |
申请日期 |
1997.11.28 |
申请人 |
EISAI CO LTD |
发明人 |
YOSHINO HIROSHI;NIIJIMA JUN;YOSHIMATSU KENTARO;KOYANAGI NOZOMU;NAGASU TAKESHI;OKADA TOSHIMI;KOTAKE YOSHIHIKO;KITO KYOSUKE;SUGUMI HIROYUKI;KAMATA JUN-ICHI;NAKAMURA KATSUJI;UENAKA TOSHIMITSU;YAMAGUCHI ATSUMI |
分类号 |
C07D471/06;C07D471/16;C07D487/06;C07D487/16;C07D491/16;C07D495/16;C07D498/06;C07D513/06 |
主分类号 |
C07D471/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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