发明名称 |
CHROMOSOME 9 AND PROGRESSIVE ROD-CONE DEGENERATION DISEASE GENETIC MARKERS AND ASSAYS |
摘要 |
Provided are nucleic acid molecules which comprise at least a portion of a polymorphic genetic marker for determining whether a canine has a mutated progressive rod-cone degeneration disease (prcd) gene locus in one or both alleles. The genetic markers are located on canine chromosome 9 in a genomic region identified as the prcd-informative region. A method for making geneti c markers representing polymorphic sequences located in the prcd-informative region of canine chromosome 9 comprises isolating a polymorphic DNA sequence in the prcd informative region, using oligonucleotides complementary with at least a portion of the sequence to amplify the sequence, and analyzing canin e chromosome 9 in a prcd-informative region for the ability of the polymorphic sequence to co-segregate with the prcd gene locus by a linkage test. The presence of a mutated prcd gene locus in one or both alleles of a canine in a pedigree is detected by analyzing canine chromosome 9 in the canine for the presence of at least one polymorphic genetic marker, which co-segregates wit h the prcd gene locus, by a linkage analysis.
|
申请公布号 |
CA2306194(C) |
申请公布日期 |
2001.05.29 |
申请号 |
CA19982306194 |
申请日期 |
1998.06.08 |
申请人 |
CORNELL RESEARCH FOUNDATION, INC. |
发明人 |
AGUIRRE, GUSTAVO;ACLAND, GREGORY;RAY, KUNAL |
分类号 |
C12Q1/68;(IPC1-7):C12Q1/68;C07H21/04;C12P19/34 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|