摘要 |
A sulfonyl divalent aromatic of Formula (I) or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity for the treatment process that comprises administering a sulfonyl divalent aromatic or heteroaromatic ring hydroxamic acid compound in an MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity. Wherein; y and z are each zero or one and the sum of z+y is one; The ring structure W is a 5- or 6-membered divalent aromatic or heteroaromatic ring; R1 is a substituent containing a 5- or 6membered cyclohydrocarbyl, heterocyclo, aryl or heteroaryl radical bonded directly to the depicted SO2-group and having a length greater than about that of a hexyl group and less than about that of an eicosyl group, the R1 defining a three-dimensional volume, when rotated about an axis drawn through the SO2 -bonded 1-position and the 4-position of a 6-membered ring radical or drawn through the SO2 -bonded 1-position and the center of 3,4-bond of a 5-membered ring radical, whose widest dimension in a direction transverse to the axis of rotation is about that of one furanyl ring to about that of two phenyl rings; and R2 and R3 are independently hydrido, C1-4hydrocarbyl, hydroxyl or amino, or R2 and R3 together with the depicted carbon atom to which they are bonded form a 6-membered heterocyclic ring in which the heteroatom is oxygen, sulfur or nitrogen, the heteroatom being optionally substituted with one or two oxygen atoms when sulfur is optionally substituted with a moiety selected from the group consisting of a C1-4hydrocarbyl, C3-6cyclohydrocarbyl, C1-4 acylhydrocarbyl, and sulfonylC1-4hydrocarbyl group when nitrogen.
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申请人 |
MONSANTO COMPANY |
发明人 |
MCDONALD, JOSEPH J;BARTA, THOMAS E;BECKER, DANIEL P;BEDELL, LOUIS J;RAO, SHASHIDAR N;FRESKOS, JOHN N;MISCHKE, BRENT V |