发明名称 |
IMMUNOTHERAPY |
摘要 |
A method is provided for enhancing the reactivity of a T cell toward a tumou r cell which method comprises: (a) isolating a T cell which is a tumour infiltrating lymphocyte (TIL) from a patient having said tumour cell present in their body; (b) introducing a nucleic acid sequence into the TIL, which sequence is capable of inhibiting or preventing expression of an endogenous Notch ligand in the TIL; and (c) re-introducing the transfected TIL into the patient; wherein the T cell comprises a T cell receptor specific for a tumou r antigen expressed by the tumour cell. |
申请公布号 |
CA2390148(A1) |
申请公布日期 |
2001.05.25 |
申请号 |
CA20002390148 |
申请日期 |
2000.11.17 |
申请人 |
LORANTIS LIMITED |
发明人 |
HOYNE, GERARD FRANCIS;LAMB, JONATHAN ROBERT |
分类号 |
A01K67/027;A61K35/14;A61K39/00;A61P35/00;A61P37/04;C12N5/08;(IPC1-7):C12N5/08;A61K48/00;C12N5/10 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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