| 摘要 |
Human sera from normal (i.e., non-HIV infected) individuals contain certain IgM autoantibodies reactive to chemokine and other lymphocyte-surface receptors. A subset of these IgM autoantibodies that bind to such receptors, particularly CXCR4 and CCR5 receptors, can inhibit HIV-1 from infecting cells. Progression from an asymptomatic HIV-1 infected state to AIDS is determined in part by the level of IgM autoantibodies that inhibit HIV-1 from infecting cells. A delicate balance exists between the level of these low avidity binding IgM autoantibodies and the viral load. Factors that predispose an individual to an increased viral load or inhibit the subset of B cells producing these autoantibodies lead to viral entry into cells and enhance virus-mediated disease progression. |
