TRANSGENIC MAMMALS INTRODUCED A <i>PERIOD 1</i> PROMOTER THAT CONFERS RHYTHMICAL EXPRESSION
摘要
The present invention relates to an isolated <i>Period 1 (Per1)</i> promoter DNA inducing rhythmical expression of a gene operably linked thereto. This invention also provides a DNA comprising a <i>Period 1</i> promoter DNA and a gene operably linked thereto, the gene being under the regulation of the promoter DNA. The present invention further provides transformants and transgenic mammals into which the DNA has been introduced. The transformants and transgenic mammals are useful in the screening of pharmaceutical drugs against diseases and disorders pertaining to the circadian rhythm.
申请公布号
WO0136618(A2)
申请公布日期
2001.05.25
申请号
WO2000JP08127
申请日期
2000.11.17
申请人
MITSUBISHI-TOKYO PHARMACEUTICALS, INC.;UNIVERSITY OF VIRGINIA PATENT FOUNDATION;TEI, HAJIME;SAKAKI, YOSHIYUKI;YAMAZAKI, SHIN;ABE, MICHIKAZU;TAKAHASHI, RI-ICHI
