发明名称 |
PEPTIDES FROM DECORIN BINDING PROTEIN AND THEIR USES |
摘要 |
<i>Borrelia burgdorferi</i>, the causative agent of Lyme desease, expresses on its surface a decorin binding protein, DbpA and DbpB. Lysine residues necessary for DbpA binding to decorin and DbpA peptides containing these critical residues essential for decorin binding are disclosed. It is further disclosed that vaccination using peptides incorporating these critical binding domains of DbpA can confer a delayed-type hypersensitivity response to DbpA and reduce the number of <i>B. burgdorferi</i> organisms present in infected animals.
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申请公布号 |
WO0077041(A3) |
申请公布日期 |
2001.05.25 |
申请号 |
WO2000US16713 |
申请日期 |
2000.06.16 |
申请人 |
THE TEXAS A & M UNIVERSITY SYSTEM |
发明人 |
HOEOEK, MAGNUS;BROWN, ERIC, L. |
分类号 |
A61K39/02;C07K14/20;C07K16/12;(IPC1-7):C07K14/20;A61K39/40;A61P31/04 |
主分类号 |
A61K39/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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