New synthetic Lipid-A analogs based on monosaccharide (1) and disaccharide (2) derivatives were designed and prepared in the present invention. Both structures (1) and (2) incorporate novel lipid structures (3) and (4) that are not found in nature. Also, novel disaccharide Lipid-A structures (2) that incorporate novel contingents of uniform lipids and where R1, R4 and R5 are the same substitution group of structure (III) were synthesized. Liposome formulations containing totally synthetic components such as synthetic Lipid-A and synthetic lipopeptide derived from tumor-associated MUC1 mucin are described along with their therapeutic utility. Comparative test results of immunostimulating properties and toxicity of Lipid-A analogs (1) and (2) are included.
申请公布号
WO0136433(A2)
申请公布日期
2001.05.25
申请号
WO2000US31281
申请日期
2000.11.15
申请人
BIOMIRA, INC.;JIANG, ZI-HUA;BACH, MIMI;YALAMATI, DAMAYANTHI;KOGANTY, RAO;LONGENECKER, MICHAEL
发明人
JIANG, ZI-HUA;BACH, MIMI;YALAMATI, DAMAYANTHI;KOGANTY, RAO;LONGENECKER, MICHAEL