Novel human protein C derivatives are described. These derivatives have increased anti-coagulation activity compared to wild-type protein C and retain the biological activity of the wild-type human protein C. These derivatives will require either less frequent administration and/or smaller dosage than wild-type human protein C in the treatment of acute coronary syndromes, vascular occlusive disorders, hypercoagulable states, thrombotic disorders and disease states predisposing to thrombosis.
申请公布号
WO0136462(A2)
申请公布日期
2001.05.25
申请号
WO2000US28884
申请日期
2000.11.06
申请人
ELI LILLY AND COMPANY;GERLITZ, BRUCE, EDWARD;GRINNELL, BRIAN, WILLIAM;HUANG, LIHUA;JONES, BRYAN, EDWARD
发明人
GERLITZ, BRUCE, EDWARD;GRINNELL, BRIAN, WILLIAM;HUANG, LIHUA;JONES, BRYAN, EDWARD