AN AQUEOUS SOLUTION FORMULATION OF ALPHA-INTERFERON

摘要

The present invention relates to an aqueous solution formulation which can retain the biological activity and physicochemical properties of alpha -interferon for a long period. More particularly, the present invention relates to an aqueous solution formulation of alpha -interferon comprising alpha -interferon; a stabilizer; an osmotic pressure regulating agent; antimicrobial preservatives selected from the group consisting of phenol, m-cresol or mixture thereof; and a buffer system. The aqueous solution formulation of the present invention has many advantages because it retains the activity of alpha -interferon for a long period, eliminates potential harmfulness to human body by minimizing the amount of the preservatives, and is very stable.