Nematode-extracted serine protease inhibitors and anticoagulant proteins

摘要

Proteins that have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF.