发明名称 |
HYDROLYTIC ENZYME SUBSTRATES AND ASSAY METHOD |
摘要 |
Compounds of the invention have the structure D-L-A*, where L is a linking moiety that maintains D and A in a configuration compatible with FRET, D is a fluorescent donor moiety capable of causing an acceptor moiety to fluoresce by FRET, and A* is a fluorescent acceptor moiety capable of accepting energy fr om the donor moiety by FRET and fluorescing only after cleavage of one or more labile groups to provide acceptor A. These compounds are useful as fluoresce nt substrates for detection of enzymes in vivo.
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申请公布号 |
CA2388904(A1) |
申请公布日期 |
2001.05.25 |
申请号 |
CA20002388904 |
申请日期 |
2000.11.03 |
申请人 |
ICONIX PHARMACEUTICALS INC. |
发明人 |
MORGANS, DAVID;JARNIGAN, KURT;LEE, VING J.;LEGER, ROGER |
分类号 |
C12Q1/00;C12Q1/34;G01N33/58;(IPC1-7):C12Q1/34;C07D307/00;C07D311/10;C07D493/10 |
主分类号 |
C12Q1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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