METHOD FOR PRODUCING ANHYDROUS PAROXETINIC HYDROCHLORIDE 2-PROPANOL SOLVATE

摘要

PROBLEM TO BE SOLVED: To provide a method for easily producing anhydrous paroxetinic hydrochloride 2-propanol solvate with simple operation. SOLUTION: This method for producing anhydrous paroxetinic hydrochloride 2-propanol solvate is characterized by dissolving paroxetine hydrochloride in a 2-propanol substantially containing water and crystallizing therefrom or is characterized by mixing a paroxetine free base or N-tert-butoxycarbonyl paroxetine with a hydrochloride 2-propanol solution substantially containing water and crystallizing therefrom.