AN ACTIVE HEDGEHOG-PROTEIN-MUTANT, A PROCESS FOR ITS PREPARATION AND ITS USE FOR PHARMACEUTICAL PURPOSES

摘要

The present invention provides isolated highly active hedgehog proteins esterified with a fatty acid having from 14 to 20 carbon atoms at the N-terminal domain of the protein. The highly active hh proteins are particularly useful therapeutic agents for treating bone disorders and neurodegenerative diseases. Methods for obtaining the highly active modified hedgehog proteins are also provided.