| 发明名称 |
METHODS TO DETECT AGENTS USEFUL TO INHIBIT NEUROFIBROMATOSIS TYPE 1 (NF1) |
| 摘要 |
A method is provided to identify inhibitors of any one of Raf, MEK, extracellular signal regulated kinase 1 (ERK1), extracellular signal regulated kinase 2 (ERK2), phosphatidylinositol triphosphate kinase (PI3K), p21 activated kinase 2 (PAK2), p21 activated kinase 3 (PAK3), Rac, CDC42, p21 activated kinase 1 (PAK1), protein kinase B (PKB), Akt, and c-jun N-terminal kinase (JNK), or crosstalk between the PI3-K an the Ras-Raf-MEK-ERK pathway, useful to treat disorders such as neurofibromatosis type 1 or at least one clinical manifestation thereof.
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| 申请公布号 |
WO0134201(A2) |
申请公布日期 |
2001.05.17 |
| 申请号 |
WO2000US30924 |
申请日期 |
2000.11.10 |
| 申请人 |
ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, INC.;ELI LILLY AND COMPANY;CLAPP, WADE, D.;INGRAM, DAVID, A.;MARSHALL, MARK, STEVEN |
发明人 |
CLAPP, WADE, D.;INGRAM, DAVID, A.;MARSHALL, MARK, STEVEN |
| 分类号 |
C12Q1/02;A61K31/00;A61K31/352;A61K31/5377;A61K45/00;A61P19/08;A61P25/00;A61P25/28;A61P35/00;A61P43/00;C12Q1/48;G01N33/68;(IPC1-7):A61K45/00 |
主分类号 |
C12Q1/02 |
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