METHOD OF TREATING A VIRAL INFECTION USING ANTAGONISTS OF MACROPHAGE COLONY STIMULATING FACTOR

摘要

A method is provided for treating a viral infection of a cell associated with increased production of M-CSF including contacting the cell with a concentration of M-CSF antagonist sufficient to inhibit replication of the virus. A method is also disclosed for treating a viral infection associated with increased production of macrophage colony stimulating factor (M-CSF), including administering to a subject a therapeutically effective amount of M-CSF antagonist that inhibits replication of the virus. In addition, a method is provided for treating a subject infected with an immunodeficiency virus including administering to the subject a therapeutically effective amount of anti-retroviral drug and co-administering to the subject a therapeutically effective amount of an antagonist of M-CSF. A pharmaceutical composition is provided for the treatment of a viral infection associated with an increased production of M-CSF, including a therapeutically effective amount of an M-CSF antagonist and a pharmaceutically acceptable carrier. The pharmaceutical composition may also include an anti-retroviral drug.