发明名称 |
PHARMACEUTICALLY ACTIVE ISOINDOLINE DERIVATIVES |
摘要 |
Isoindolin-1-one and Isoindoline-1, 3-dione substituted in the 2-position with an alpha -(3, 4-disubstituted phenyl)alkyl group and in the 4- and/or 5-position with a nitrogen-containing group are inhibitors of, and thus useful in the treatment of disease states mediated by, TNF alpha and phosphodiesterase. A typical embodiment is 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4,5-diaminoisoindoline-1,3-dione.
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申请公布号 |
WO0134606(A1) |
申请公布日期 |
2001.05.17 |
申请号 |
WO2000US30770 |
申请日期 |
2000.11.09 |
申请人 |
CELGENE CORPORATION;MAN, HON-WAH;MULLER, GEORGE |
发明人 |
MAN, HON-WAH;MULLER, GEORGE |
分类号 |
A61K31/135;A61K31/16;A61K31/198;A61K31/325;A61K31/4035;A61K31/4178;A61K31/4188;A61K31/4196;A61K31/4245;A61K31/437;A61K31/4745;A61K31/4985;A61P1/00;A61P11/06;A61P11/08;A61P19/02;A61P29/00;A61P31/18;A61P31/22;A61P35/00;A61P37/06;A61P43/00;C07C403/04;C07D209/46;C07D209/48;C07D209/49;C07D403/04;C07D403/06;C07D413/04;C07D471/04;C07D487/04;(IPC1-7):C07D487/04;A61K31/418;A61K31/498;A61K31/424;A61K31/419;A61K31/417;A61K31/403 |
主分类号 |
A61K31/135 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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