发明名称 |
USE OF CASPASE-14 AND CASPASE-14 MODULATORS TO DIAGNOSE AND/OR TREAT SKIN, EYE AND BRAIN DISORDERS |
摘要 |
The present invention is based on the finding that caspase-14 is expressed i n epithelial tissue such as the epidermis, the epithelial layer of the choroid plexus and the pigmented retinal layer. The invention relates to the involvement of caspase-14 in keratinocyte differentiation and in a properly functioning blood-brain barrier and blood-eye barrier. The present invention specifically relates to nucleic acids encoding caspase-14, caspase-14 protei n and modulators of caspase-14 expression, activation and bioactivity that can be used to diagnose and/or treat keratinocyte differentiation disorders, disturbances in the blood-eye barrier and brain disorders. |
申请公布号 |
CA2390510(A1) |
申请公布日期 |
2001.05.17 |
申请号 |
CA20002390510 |
申请日期 |
2000.11.10 |
申请人 |
VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW |
发明人 |
LIPPENS, SASKIA;VANDENABEELE, PETER;DECLERCQ, WIM |
分类号 |
A61K31/203;A61K31/573;A61K31/593;A61K31/7088;A61K33/06;A61K33/14;A61K38/18;A61K38/48;A61K39/395;A61P17/00;A61P25/00;A61P27/00;C07K16/40;C12N9/64;C12Q1/68 |
主分类号 |
A61K31/203 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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