METHODS AND COMPOSITIONS FOR PEPTIDE SYNTHESIS

摘要

The present invention relates, first, to methods for the synthesis of peptid es referred to as T-1249 and T-1249-like peptides. Such methods utilize solid a nd liquid phase synthesis procedures to synthesize and combine groups of specif ic peptide fragments to yield the peptide of interest. The present invention further relates to individual peptide fragments which act as intermediates i n the synthesis of the peptides on interest (e.g., T-1249). The present invention still further relates to groups of such peptide intermediate fragments which can be utilized together to produce full-length T-1249 and T - 1249-like peptides.