发明名称 |
Monoester derivatives of nucleosides or nucleoside analogs and pharmaceutical preparations in which they are comprised |
摘要 |
Fatty acid esters (I) of nucleosides or nucleoside analogues are new, where the fatty acid is a monounsatd. 18 to 20C fatty acid esterified with the 5'-OH gp. of nucleosides or with an OH gp. on the noncyclic chain of nucleoside analogues. (I) have higher activity than the parent nucleosides or analogues and have relatively low toxicity. Pref., (I) are esters of acyclovir, Ara T, Ara A or AZT with oleic acid, elaidic acid or cis- or trans-eicosenic acid.
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申请公布号 |
CZ288153(B6) |
申请公布日期 |
2001.05.16 |
申请号 |
CZ19940000805 |
申请日期 |
1992.09.30 |
申请人 |
NORSK HYDRO A. S. |
发明人 |
DALEN ARE;MYHREN FINN;BORRETZEN BERNT;STOKKE KJELL TORGEIR |
分类号 |
A61K31/505;A61K31/52;A61K31/522;A61K31/70;A61K31/7042;A61K31/7052;A61K31/7064;A61K31/7068;A61K31/7072;A61K31/7076;A61K31/708;A61P31/12;A61P31/18;C07D239/54;C07D473/00;C07D473/18;C07D473/34;C07H19/02;C07H19/06;C07H19/067;C07H19/073;C07H19/09;C07H19/16;C07H19/167;C07H19/173;C07H19/19;(IPC1-7):C07H19/06;A61K31/705 |
主分类号 |
A61K31/505 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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