| 摘要 |
In the present invention there are disclosed 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracykline compounds of the general formula I, in which R represents hydrogen; Re1 represents hydrogen or alkyl containing 1 to 3 carbon atoms; W represents an amino group, being optionally substituted with one group being selected from a group comprising alkyl having 1 to 8 carbon atoms, cycloalkylmethyl containing 3 to 6 carbon atoms in the cycloalkyl moiety, phenylmethyl, pyridylmethyl and thienylmethyl or with two alkyl groups having 1 to 3 carbon atoms; N-pyrrolidinyl or N-piperidyl, whereby each of the later groups can be optionally substituted with one methyl; and their pharmacologically acceptable salts with organic or inorganic acids. The compounds of the general formula III, in which Y represents bromine, chlorine, iodine or fluorine and R and Re1 are as specified above and their salts with organic and inorganic acids as intermediates for preparing the compounds of the general formula I. A process for preparing the compounds of the general formula I by reacting the compound of the general formula III with nucleophilic compound of the general formula WH, wherein W is as specified above in a polar aprotic solvent and in inert atmosphere. A process for preparing the compounds of the general formula I by reacting the compound of the general formula 1, wherein R represents hydrogen with a chloride of the compound of the general formula (R,Re1,W)C-C(=O)X, in which R and Re1 and W are as specified above and X represents bromine, chlorine, iodine or fluorine, in an inert solvent and in polar aprotic solvent in the presence of a base. In the present invention there are also claimed pharmaceutical and veterinary preparations based on the compounds of the general formula I. The compounds of the general formula I are antibacterial agents.
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