发明名称 |
MONOCLONAL AND CHIMERIC ANTIBODIES SPECIFIC FOR HUMAN TUMOR NECROSIS FACTOR |
摘要 |
<p>Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-a (TNFa) and are useful in vivo diagnosis and therapy of a number of TNFa-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.</p> |
申请公布号 |
EP0610201(B1) |
申请公布日期 |
2001.05.16 |
申请号 |
EP19920910625 |
申请日期 |
1992.03.18 |
申请人 |
NEW YORK UNIVERSITY;CENTOCOR INC. |
发明人 |
LE, JUNMING;VILCEK, JAN;DADDONA, PETER E.;GHRAYEB, JOHN;KNIGHT, DAVID M.;SIEGEL, SCOTT A. |
分类号 |
A61K39/395;A61K35/00;A61K38/00;A61P1/04;A61P1/16;A61P3/10;A61P5/14;A61P7/00;A61P9/10;A61P17/00;A61P19/02;A61P29/00;A61P31/04;A61P31/10;A61P31/12;A61P35/00;A61P37/00;A61P37/02;C07K1/22;C07K7/06;C07K7/08;C07K14/52;C07K14/525;C07K16/00;C07K16/24;C07K16/46;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/13;C12P21/02;C12P21/08;C12R1/91;G01N33/53;G01N33/577;(IPC1-7):C12N15/13;C07K1/00;G01N33/68 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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