| 摘要 |
A transmyocardial revascularization system including a plurality of inserts formed of a material to elicit a healing response in tissue of the myocardiu m and deployment instruments and associated components for deploying the inser ts into the wall of the myocardium. The inserts are arranged to be disposed within respective lumens or channels in the wall of the myocardium. The inserts can take various forms, e.g., be solid members, tubular members, or porous members, and may be resorbable, partially resorbable or non-resorbabl e. In some embodiments the inserts are arranged to be left in place within the channels in the wall of the myocardium to result in plural lumens which enab le blood to flow therethrough and into contiguous capillaries. The deployment instruments are arranged to pierce the tissue of the myocardium from either the endocardium or the epicardium to insert the inserts into the myocardium, depending on the particular deployment instrument used. The deloyment instruments may make use of a stabilizing device to stabilize them during th e procedure of inserting the inserts into the myocardium. A controller may als o be provided as part of the system to coordinate the operation of the deployment instrument with the cardiac cycle. The formation of the lumens ca n be achieved either bythe inserts or by some other means, such as a piercing tip or an energy applicator forming a portion of the instrument. The inserts may include one or more of pharmaceuticals, biologically active agents, radiopaque materials, etc. |
