发明名称 |
Treatments based on discovery that nitric oxide synthase is a paraquat diaphorase |
摘要 |
Paraquat has been found to accept electrons from nitric oxide synthase (NOS) whereupon the reduced paraquat generates toxic O2- and prevents NOS from giving electrons to arginine and thereby inhibits NO production. This is generalized for compounds with a redox potential greater than nitric oxide synthase. The compounds inhibit nitric oxide synthase and kill cells including NOS by generating O2- and also by depriving the cells of the NO which they need. Applications include treating paraquat-induced injury and pathologically proliferating cells (tumors, restenosis benign prostatic hypertrophy, pulmonary hypertension, infective pathogens).
|
申请公布号 |
US6231894(B1) |
申请公布日期 |
2001.05.15 |
申请号 |
US19990421942 |
申请日期 |
1999.10.21 |
申请人 |
DUKE UNIVERSITY;NATIONAL JEWISH MEDICAL AND RESEARCH CENTER;CORNELL RESEARCH FOUNDATION, INC. |
发明人 |
STAMLER JONATHAN S.;DAY BRIAN J.;GROSS STEVEN S.;GRIFFITH OWEN W. |
分类号 |
A61K31/00;A61K31/223;A61K31/44;A61K31/4425;A61K31/444;A61K31/4985;A61K33/00;(IPC1-7):A61K33/00;A61K31/04 |
主分类号 |
A61K31/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|