ANTIINFLAMATORY COMPOSITION CONTAINING -CARBOLINE DERIVATIVES

摘要

PURPOSE: An antiinflammatory agent containing β-carboline derivatives and pharmaceutically acceptable carriers is provided, which can express an antiinflammatory effect through simultaneous inhibiting action on iNOS and COX-2. CONSTITUTION: This antiinflammatory agent contains β-carboline derivatives of formula 1 and pharmaceutically acceptable carriers, wherein the β-carboline derivatives are obtained by extracting and purifying Melia azedarach L. In the formula, R represents H or C1-5 alkoxy. The β-carboline derivatives are 4-methoxy-1-vinyl-β-carboline of formula 2 and 4,8-dimethoxy-1-vinyl-β-carboline of formula 3.