| 摘要 |
PURPOSE: Live attenuated bacteria for use as a medicament are provided, which are useful for the prevention of microbial pathogenesis and carry a heterologous gene and vaccines based thereon. CONSTITUTION: The live attenuated vaccine for the protection of animals against infection with a pathogenic bacterium or the pathogenic effects thereof comprises a live attenuated bacterium that is incapable of expressing a functional Cra protein as a result of a mutation in the cra gene, and a pharmaceutically acceptable carrier. The pathogenic bacterium belongs to any of the genera Escherichia, Salmonella, Actinobacillus, Haemophilus, Aeromonas, Pasteurella, Streptococcus and Yersinia.
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