9-(3,5-DIMETHOXYPHENYL)-5,8,8a,9-TETRAHYDROFURO-(3',4':6,7)NAPHTHO(2,3-d)(1,3)DIOXOL-6(5aH)-ONE COMPOUNDS, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

摘要

PURPOSE: Provided are 9-(3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro-(3',4':6,7)naphtho(2,3-d)(1,3)dioxol-6(5aH)-one compounds which are natural products useful for the treatment of cancer, their preparation method, and a pharmaceutical composition containing them. CONSTITUTION: 9-(3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro-(3',4':6,7)naphtho(2,3-d)(1,3)dioxol-6(5aH)-one compound is represented by the formula(I), wherein wherein:R represents:a group of formula(I): wherein X, Y and W are as defined in the description,or a group of formula(II) of -A-G: wherein:A represents a single bond or an optionally substituted alkylene chain,G represents a group selected from hydrogen, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, -OR2, -O-T1-NR3R4, -O-T1-NR2-T'1-NR3R4, -NR3R4, -NR2-T1-NR3R4, -NR2-T1-OR5, -NR2-T1-CO2R6, -NR2-T1-C(O)R6, -C(O)-NR3R4, -C(O)-NR2-T2, -O-C(O)T2, -O-C(S)-T2, -NR2-C(O)-T2, -NR2-C(S)-T2, -O-C(O)-O-T2, -O-C(O)-NR2-T2, -O-C(S)-O-T2, -O-C(S)-NR2-T2, -NR2-C(O)-O-T2, -NR2-C(O)-NR-T2, -NR2-C(S)-O-T2, -NR2-C(S)-NR6-T2 and -NR2-SO2-T3, wherein R2, R3, R4, R5, R6, T1, T'1, T2 and T3 are as defined in the description,R1 represents a group selected from hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, heterocycloalkylcarbonyl, alkylsulphonyl, arylsulphonyl, arylalkylsulphonyl, phosphono, aryloxycarbonyl, alkoxycarbonyl and arylalkoxycarbonyl,its isomers, and also addition salts thereof with a pharmaceutically acceptable acid or base.Medicinal products containing the same which are useful in the treatment of cancer.