PRODUCTION OF CHIRAL ESTER

摘要

PURPOSE: A process for preparing the title compound by using a catalytic system such as ruthenium complex and lipase from lacemic alcohol is provided, thereby producing the chial ester having excellent optical purity characteristics in a simple manner in high yield by producing almost no ketone as side products. CONSTITUTION: The chiral ester of formula 100 is prepared by the reaction of: racemic alcohol of formula 4; a ruthenium complex selected from formula 1 to 3 that accelerates racemization of the racemic alcohol; lipase that selectively acylates one enantiomer of the racemic alcohol; and an acyl donner that supplies an acyl group to the lipase.