| 摘要 |
<p>The present invention relates to a compound of the formula (I) wherein R1 is benzofuranyl substituted by halogen, or styryl substituted by halogen, R2 is phenyl, pyridyl, thienyl or thiazolyl, each of which is optionally substituted by one or more substituents, or lower alkyl optionally substituted by one or more halogen atoms, R3 is hydrogen or lower alkoxy, R?4 and R5¿ are the same or different and each is hydrogen, lower alkyl or optionally protected hydroxy(lower)alkyl, and R6 is hydrogen or lower alkyl, or pharmaceutically acceptable salts thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof possess a strong inhibitory activity on the production of nitric oxide (NO), and are useful for prevention and/or treatment of NO-mediated diseases in human being and animals.</p> |
