发明名称 |
COMPOSITIONS AND METHODS FOR DETERMINING INTERACTIONS OF MITOCHONDRIAL COMPONENTS, AND FOR IDENTIFYING AGENTS THAT ALTER SUCH INTERACTIONS |
摘要 |
Compositions and methods are provided for identifying agents that alter mitochondrial membrane permeability transition. The screening methods generally detect agents that alter the interaction between the mitochondrial adenine nucleotide translocator and cyclophilin D. Such agents may be used, for example, in the treatment of a variety of conditions associated with altered mitochondrial function.
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申请公布号 |
CA2389754(A1) |
申请公布日期 |
2001.05.10 |
申请号 |
CA20002389754 |
申请日期 |
2000.11.03 |
申请人 |
MITOKOR |
发明人 |
MURPHY, ANNE N.;CLEVENGER, WILLIAM;WILEY, SANDRA E.;ANDREYEV, ALEXANDER Y.;FRIGERI, LUCIANO G.;VELICELEBI, GONUL;DAVIS, ROBERT E. |
分类号 |
C07K14/435;C07K14/47;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/90;C12N15/09;C12N15/12;C12N15/61;C12N15/62;C12P21/02;C12Q1/02;G01N33/15;G01N33/50;G01N33/53;G01N33/542;G01N33/566;(IPC1-7):C12N15/12;G01N33/533;G01N33/68 |
主分类号 |
C07K14/435 |
代理机构 |
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代理人 |
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地址 |
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