发明名称 |
POLYPEPTIDES WITH NON-NATURAL PRIMARY SIGNALLING MOTIFS |
摘要 |
The invention relates to non-natural stimulatory primary signalling motifs, which contain the consensus amino acid sequence of Y-X2-L/I-X6-8-Y-X2-L/I. These motifs are extremely efficient at mediating immune cell signal transduction, particularly when incorporated in an intracellular signalling domain of a chimeric receptor. Nucleic acids that encode, and polypeptides that contain, such non-natural stimulatory primary signalling motifs are described, which are suitable for use in medicine.
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申请公布号 |
WO0132709(A2) |
申请公布日期 |
2001.05.10 |
申请号 |
WO2000GB04183 |
申请日期 |
2000.11.01 |
申请人 |
CELLTECH CHIROSCIENCE LIMITED;FINNEY, HELENE, MARGARET;LAWSON, ALASTAIR, DAVID, GRIFFITHS |
发明人 |
FINNEY, HELENE, MARGARET;LAWSON, ALASTAIR, DAVID, GRIFFITHS |
分类号 |
C12N15/09;A61K35/76;A61K38/00;A61K48/00;A61P3/10;A61P7/06;A61P11/06;A61P17/00;A61P17/06;A61P25/00;A61P29/00;A61P31/00;A61P31/18;A61P35/00;A61P37/00;A61P37/06;C07K14/47;C07K14/705;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/12;(IPC1-7):C07K14/705;C12N15/62;A61K38/17 |
主分类号 |
C12N15/09 |
代理机构 |
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地址 |
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