Hybrid matrices and hybrid matrix mixtures

摘要

A composition having a body of matrix material made up of insoluble collagen fibrils, and disposed therewithin: a) a plurality of vertebrate cells; b) a plurality of microcarriers; and c) an agent such as a factor that promotes vascularization, a cytokine, a growth factor, or ascorbic acid. The invention also features a method of delivering a polypeptide to an animal. The method involves introducing into the animal a fluid mixture containing: a) a population of cultured vertebrate cells genetically engineered to express the polypeptide; and b) a plurality of microcarriers.