发明名称 |
POLIKETIDA DAN SINTESISNYA |
摘要 |
A polyketide synthase ("PKS") of Type I is a complex multienzyme including a loading domain linked to a multiplicity of extension domains. The first extension module receives an acyl starter unit from the loading domain and each extension module adds a further ketide unit which may undergo processing (e.g. reduction). We have found that the Ksq domain possessed by some PKS's has decarboxylating activity, e.g. generating (substituted) acyl from (substituted) malonyl. The CLF domain of type II PKS's has similar activity. By inserting loading modules including such domains into PKS's not normally possessing them it is possible to control the starter units used. |
申请公布号 |
ID28285(A) |
申请公布日期 |
2001.05.10 |
申请号 |
ID20010000219 |
申请日期 |
1999.06.29 |
申请人 |
BIOTICA TECHNOLOGY LIMITED;PFIZER INC |
发明人 |
PETER FRANCIS LEADLEY;JAMES STAUNTON;JESUS CORTES;HAMISH ALASTAIR IRVINE MCARTHUR |
分类号 |
A01H5/00;A01K67/027;A61K31/7042;A61K31/7048;A61P31/04;C07H17/08;C07K19/00;C12N5/10;C12N9/10;C12N11/18;C12N15/00;C12N15/09;C12N15/52;C12P17/06;C12P17/08;C12P19/62 |
主分类号 |
A01H5/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|