NOVEL INDOLE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT

摘要

Indole derivatives of general formula (1) or salts thereof; drugs containing the derivatives or the salts as the active ingredient; and intermediates for the preparation of the same: [wherein R<1> is an amino-protecting group or COR<8> (wherein R<8> is aryl or the like); R<2> is H, alkyl, aryl, or the like; R<3> is cyano, -COR<9> (wherein R<9> is H, alkyl, or the like), or S(O)n-R<12> (wherein R<12> is alkyl, aralkyl, aryl, or the like; and n is an integer of 0 to 2); and R<4>, R<5>, R<6> and R<7> are each independently H, alkyl, alkynyl, aralkyl, alkoxy, aralkyloxy, halogeno, trifluoromethanesulfonyloxy, aryl, or the like]. The compounds (1) or salts thereof exhibit an excellent chymase activity and are useful as preventive or therapeutic drugs for circulatory diseases, inflammation, immunologic diseases, allergic diseases, eye diseases, complications of diabetes, collagen disease, and obesity.