发明名称 |
Process for obtaining growth factor preparations (tgf-beta and igf-1) from milk products having low mutual cross-contamination |
摘要 |
The present invention relates to a process for extracting transforming growth factor beta (TGF- beta ) and insulin-like growth factor 1 (IGF-1) from a milk product, comprising the steps of: a) recovering a basic fraction from the milk product by means of cationic exchange chromatography; b) passing the fraction obtained in step a) over a hydroxyapatite column; c) eluting the hydroxyapatite column with appropriate eluents in such a way as to obtain two separate fractions, these fractions being: i) a fraction comprising IGF-1 in the substantial absence of TGF- beta ; ii) a fraction comprising TGF- beta in the substantial absence of IGF-1. This process can comprise a further step d) in which a lactoperoxidase fraction can be obtained. The invention further relates to the products obtained with this process. |
申请公布号 |
AU6232999(A) |
申请公布日期 |
2001.05.10 |
申请号 |
AU19990062329 |
申请日期 |
1999.10.06 |
申请人 |
CAMPINA MELKUNIE B.V.;N.V. NUTRICIA |
发明人 |
MARINUS GERARDUS CORNELIS KIVITS;ANDOR WILHELM JOSEPH HENDRICKS;LEONARD FRANCISCUS MALLEE |
分类号 |
A23J1/20;C07K14/495;C07K14/65 |
主分类号 |
A23J1/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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