| 摘要 |
<p>The present invention is related to a pH insensitive drug delivery device, specifically an osmotic pump, for the controlled release of a beneficial agent in an environment of use, which comprises (a) a core prepared from an admixture comprising: (i) a therapeutically effective amount of at least one beneficial agent, or salts thereof, that has a solubility profile that is dependent on the pH level of the environment of use; and (ii) at least one pH modulating agent; and (b) a controlled porosity, microporous coating which surrounds the core. In a second embodiment, the invention is also related to a pH insensitive, osmotic drug delivery device for the controlled release of a beneficial agent in an environment of use, which comprises (a) a core containing a therapeutically effective amount of at least one beneficial agent, or salts thereof, that has a solubility profile that is dependent on the pH level of the environment of use; and b) a controlled porosity, microporous coating which surrounds the core and has at least one aperture.</p> |
