发明名称 |
NUCLEIC ACID VACCINE COMPOSITIONS HAVING A MAMMALIAN CD80/CD86 GENE PROMOTER DRIVING ANTIGEN EXPRESSION |
摘要 |
<p>Polynucleotides encoding at least one immunizing antigen whose expression is controlled by a promoter derived from a gene encoding a co-stimulatory molecule are provided. The polynucleotides may also encode adjuvants. Compositions comprising at least one immunizing agent and at least one cytokine that enhance dendritic cell stimulation and/or survival are also provided. Methods for eliciting an immune response against the immunizing agent are also provided. The method includes the steps of administering the polynucleotides and, optionally, co-administering an adjuvant.</p> |
申请公布号 |
CA2389680(A1) |
申请公布日期 |
2001.05.10 |
申请号 |
CA20002389680 |
申请日期 |
2000.11.01 |
申请人 |
POWDERJECT VACCINES, INC. |
发明人 |
UMLAUF, SCOTT |
分类号 |
C12N15/09;A61K9/14;A61K38/00;A61K39/00;A61K39/21;A61K39/29;A61K47/02;A61K48/00;A61P31/00;A61P31/04;A61P31/10;A61P31/12;A61P35/00;A61P37/04;A61P37/08;A61P43/00;C07K14/475;C07K14/705;(IPC1-7):A61K39/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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