PRODUCTION OF POLYMORPHIC FORMS I AND II OF FINASTERIDE BY COMPLEXATION WITH GROUP I OR II METAL SALTS

摘要

Polymorphic Form (I) finasteride is prepared by first forming a substantially insoluble complex of finasteride and a Group (I) or Group (II) metal salt, such as lithium bromide, and then dissociating the complex by dissolving away the salt component with water, so as to obtain substantially pure Form (I) polymorphic crystalline finasteride.