发明名称 |
Peptide derivatives |
摘要 |
Compounds represented by the following general formula and salts thereof; Y-L-Tyr-Q-NR1-CH(R2)-CO-X, wherein R1 represents hydrogen or C1-6 alkyl; R2 represents optionally substituted benzyl; Q represents D- or L-Arg; Y represents two hydrogen atoms of N-terminal amino group of L-Tyr, or one or two functional groups substituting for the hydrogen atoms, for example, a C1-6 alkyl optionally having amino or carboxy; and X represents N-methyl-beta-alanine and other. The compounds have analgesic effect and can be used for the treatment of cancer pain or the like.
|
申请公布号 |
US6228841(B1) |
申请公布日期 |
2001.05.08 |
申请号 |
US19980029604 |
申请日期 |
1998.04.28 |
申请人 |
DAIICHI PHARMACEUTICAL CO., LTD.;FUJI CHEMICAL INDUSTRIES, LTD. |
发明人 |
SAKURADA SHINOBU;OKAYAMA TORU;NUKUI ERIKO;HONGO KAZUYA;OGAWA TADASHI;HONGO TOMOKO;TAKESHIMA SATOKO;TAKE NOBUHIRO;NAKANO MASAHARU |
分类号 |
A61K38/00;C07K5/02;C07K7/02;(IPC1-7):A61K38/07 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|