Antisense oligonucleotide modulation of tumor necrosis factor-(alpha) (TNF-alpha) expression

摘要

Compositions and methods are provided for inhibiting the expression of human tumor necrosis factor-alpha (TNF-alpha). Antisense oligonucleotides targeted to nucleic acids encoding TNF-alpha are preferred. Methods of using these oligonucleotides for inhibition of TNF-alpha expression and for treatment of diseases, particularly inflammatory and autoimmune diseases, associated with overexpression of TNF-alpha are provided.