发明名称 |
11beta-aryl substituted 14,17-ethanoestratriens, method for the production of these compounds and their use in the production of medicaments |
摘要 |
This invention describes 11beta-aryl-substituted 14,17-ethanoestratrienes of general formula (I). The new compounds are selective estrogens whose action occurs in a tissue-selective manner. The estrogenic action occurs in particular on bone, in the cardiovascular system and in the CNS (central nervous system). Only a slight estrogenic action or no estrogenic action occurs in the uterus and in the liver, however. The compounds are suitable for the production of pharmaceutical agents for use in numerous indications (for example for hormone replacement therapy, prevention and treatment of osteoporosis).
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申请公布号 |
US6229029(B1) |
申请公布日期 |
2001.05.08 |
申请号 |
US20000424913 |
申请日期 |
2000.06.09 |
申请人 |
SCHERING AKTIENGESELLSCHAFT |
发明人 |
BOHLMANN ROLF;FRITZEMEIER KARL HEINRICH;HEGELE-HARTUNG CHRISTA;KNAUTHE RUDOLF;PARZCYK KARSTEN |
分类号 |
A61K31/565;A61P5/32;A61P19/10;A61P43/00;C07J41/00;C07J53/00;(IPC1-7):C07D245/00 |
主分类号 |
A61K31/565 |
代理机构 |
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代理人 |
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地址 |
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