发明名称 |
Composition and method of preparing microparticles of water-insoluble substances |
摘要 |
Pharmaceutical compositions containing cyclosporin microparticles are prepared by applying energy to cyclosporin particles in the presence of phospholipid and one or more surface modifiers. These microparticles consist essentially of cyclosporin, a phospholipid and at least one surface modifier. The surface modifier or surface modifiers yield particles of a volume-weighted mean particle size the cyclosporin about 50% smaller than cyclosporin particles produced in the presence of a phospholipid only and without the presence of the surface modifier using the same energy input.
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申请公布号 |
US6228399(B1) |
申请公布日期 |
2001.05.08 |
申请号 |
US19980218080 |
申请日期 |
1998.12.22 |
申请人 |
RESEARCH TRIANGLE PHARMACEUTICALS |
发明人 |
PARIKH INDU;SELVARAJ ULAGARAJ |
分类号 |
A61K9/50;A61K9/10;A61K9/14;A61K9/51;A61K47/06;A61K49/00;A61K49/04;(IPC1-7):A61K9/14;A61K47/32;G01N33/92 |
主分类号 |
A61K9/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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