发明名称 Novel substituted succinic acid metallo-beta-lactamase inhibitors and their use in treating bacterial infections
摘要 This invention relates to novel substituted succinic acid metallo-beta-lactamase inhibitors which are useful potentiators of beta-lactam antibiotics. Accordingly, the present invention provides a method of treating bacterial infections in animals or humans which comprises administering, together with a b-lactam antibiotic, a therapeutically effective amount of a compound of formula I: including pharmaceutically acceptable salts, prodrugs, anhydrides, and solvates thereof.
申请公布号 AU1350401(A) 申请公布日期 2001.05.08
申请号 AU20010013504 申请日期 2000.10.27
申请人 MERCK AND CO., INC. 发明人 JAMES M. BALKOVEC;MARK L. GREENLEE;STEVEN H. OLSON;GREGORY P. ROUEN
分类号 C07D233/60;A61K31/194;A61K31/407;A61K31/4164;A61K31/4985;A61K45/00;A61P31/04;A61P43/00;C07C57/38;C07C57/58;C07C59/64;C07C69/612;C07C69/734;C07C229/34;C07C257/14;C07C271/22;C07C279/14;C07D307/91;C07D333/20;C07D405/06;C07D409/06;C07D487/18;C07D521/00 主分类号 C07D233/60
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