| 摘要 |
A method of preventing necrotizing tissue injury in gastro-intestinal tract comprising orally administering glutamine is described. Glutamine protects tissues along the gastro-intestinal tract by blocking translocation of bacterial agents (such as gram (-) bacteria), other infectious agents, toxin s, chemicals, and injurious substances. The intraluminal/apical presence of the glutamine optimizes mucosal defense and increases nutrient absorption. Glutamine may be administered to pre-term or full-term infants, children and adults. Enteral glutamine is useful in treating neonatal necrotizing enterocolitis for reducing inflammation caused by bacterial translocation an d injury. Oral glutamine is also useful in treating gastro-intestinal dysfunctions. When glutamine is orally administered it coats gastro-intestin al mucosa thereby treating infectious and/or inflammatory conditions of the gastro-intestinal tract. It is useful in treating pathologic conditions with lowered transepithelial electrical resistance (TEER) by acting as a curative agent. Glutamine may be provided in any form such as powder, capsules, acid- resistant slow-release microcapsules, in a reconstituted liquid or the like. Glutamine may also be orally administered in a mixture. Other drugs for treatment may also be administered with the glutamine. Glutamine is administrable via naso-gastric tube, especially for preterm infants. |
