METHOD FOR PRODUCING CLARITHROMYCIN CRYSTAL FORM II

摘要

PROBLEM TO BE SOLVED: To obtain a high-purity clarithromycin crystal form II in a high yield. SOLUTION: Pure clarithromycin crystal form II can be produced by a simple high-yield process including stages for treating crude clarithromycin or clarithromycin of another crystal form with formic acid in an organic solvent to form crystalline clarithromycin formate and neutralizing clarithromycin formate with a base in a mixture of water and a water-compatible organic solvent.