发明名称 |
METHOD FOR PR-39 PEPTIDE REGULATED STIMULATION OF ANGIOGENESIS |
摘要 |
The present invention provides both a method and means for regulating angiogenesis within living cells, tissues, and organs in-situ. The regulation is performed using native PR-39 peptide or one of its shorter-length homolog, for interaction with such proteasomes as one present in the cytoplasm of viable cells. The result of PR-39 peptide interaction with proteasomes is a decrease in the intracellular degradation of active peptides such as HIF-1 alpha and a consequential stimulation of angiogenesis in-situ.
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申请公布号 |
WO0130368(A1) |
申请公布日期 |
2001.05.03 |
申请号 |
WO2000US27552 |
申请日期 |
2000.10.06 |
申请人 |
BETH ISRAEL DEACONESS MEDICAL CENTER |
发明人 |
SIMONS, MICHAEL;GAO, YOUHE |
分类号 |
A61K38/00;A61K48/00;C07K14/81;(IPC1-7):A61K38/00;A61K38/08;A61K38/16;C07K7/00;C07K7/04;C07K7/06 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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